Free US shipping on orders $250+ · Research Use Only · 14-Day Risk-Free Guarantee
Melanotan II
Melanotan II (MT-II) is a cyclic heptapeptide analogue of α-MSH. Synthesized at >99% purity for research into melanocortin receptor biology. Supplied strictly for in-vitro and laboratory research use only.
$46.99
14-day risk-free guarantee · Free US shipping on orders $250+
COA / Batch Lookup
Search certificates of analysis by batch number
Get Started →
Dosage — 10mg selected
Subscribe & Save
Buy 1
$46.99 each
$46.99
Most Popular
Buy 2 Save 5%
$44.64 each
$89.28
$93.98
Best Value
Buy 3+ Save 10%
$42.29 each
$126.87
$140.97
Subscribe & Save
Discounted per-vial pricing | No hidden fees
1
14-day risk-free guarantee · Secure checkout
Research Use Only — Not for Human Consumption
Melanotan II has been studied across melanocortin receptor biology and pigmentation research:
- Potent MC1R agonist — stimulates melanogenesis and eumelanin production in melanocyte cell culture models
- MC3R and MC4R activity studied in the context of energy homeostasis and appetite regulation in rodent models
- Originally developed at University of Arizona as a tool for studying UV-independent melanogenesis in vivo
- Cyclic lactam structure provides greater metabolic stability vs. linear α-MSH in preclinical studies
- Studied in sexual function research via MC4R pathway activation in animal models
Every batch is independently tested by a US-based third-party laboratory:
Search COA Library →
- Identity: confirmed by HPLC and mass spectrometry
- Purity: >99% by HPLC
- Endotoxin: <1 EU/mg
- Appearance: white to off-white lyophilized powder
Search COA Library →
- Hadley ME, Dorr RT. (2006). Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization. Peptides. 27(4):921–930.
- Wikberg JE. (1999). Melanocortin receptors: perspectives for novel drugs. Eur J Pharmacol. 375(1–3):295–310.
- Lim CT, et al. (2010). Melanocortin receptors and their role in obesity. Peptides. 31(3):428–440.
Frequently Paired Compounds
GHK-Cu
Copper Peptide
Glutathione
Master Antioxidant
BAC Water
Reconstitution Solution
meet the collection.
Made With
mt-ii
peptide · melanocortin analogue
Melanotan II (MT-II) is a synthetic cyclic heptapeptide analogue of α-MSH, synthesized to >99% purity in a US-based cGMP facility. Every batch independently tested and COA published publicly. Supplied for in-vitro and laboratory research use only.
a melanocortin analogue for pigmentation + receptor research.
Purity>99% by HPLC
FormLyophilized powder
Endotoxin<1 EU/mg
Storage−20°C · 28 days reconstituted
TestingThird-party verified · USA synthesized
FYIResearch Use Only · Not for human use
Melanotan II has been studied across melanocortin receptor biology and pigmentation research:
- Potent MC1R agonist — stimulates melanogenesis and eumelanin production in melanocyte cell culture models
- MC3R and MC4R activity studied in the context of energy homeostasis and appetite regulation in rodent models
- Originally developed at University of Arizona as a tool for studying UV-independent melanogenesis in vivo
- Cyclic lactam structure provides greater metabolic stability vs. linear α-MSH in preclinical studies
- Studied in sexual function research via MC4R pathway activation in animal models
Every batch is independently tested by a US-based third-party laboratory:
Search COA Library →
- Identity: confirmed by HPLC and mass spectrometry
- Purity: >99% by HPLC
- Endotoxin: <1 EU/mg
- Appearance: white to off-white lyophilized powder
Search COA Library →
- Hadley ME, Dorr RT. (2006). Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization. Peptides. 27(4):921–930.
- Wikberg JE. (1999). Melanocortin receptors: perspectives for novel drugs. Eur J Pharmacol. 375(1–3):295–310.
- Lim CT, et al. (2010). Melanocortin receptors and their role in obesity. Peptides. 31(3):428–440.
Support
common questions.
Everything you need to know about Melanotan II for your research. Can't find an answer? Contact our team directly.
Melanotan II (MT-II) is a synthetic cyclic heptapeptide analogue of α-MSH. It was developed at the University of Arizona as a research tool for studying melanocortin receptor biology without UV exposure. MT-II binds with high affinity to MC1R (driving melanogenesis), MC3R and MC4R (metabolic and sexual function pathways), and MC5R. Its cyclic lactam structure confers greater resistance to enzymatic degradation compared to linear α-MSH in preclinical studies.
Melanotan I (afamelanotide) is a linear analogue of α-MSH with high selectivity for MC1R and limited activity at other melanocortin receptors. MT-II is a cyclic analogue with broader receptor activity (MC1R, MC3R, MC4R, MC5R). Afamelanotide has received regulatory approval for erythropoietic protoporphyria in some jurisdictions. MT-II remains a research compound with no approved therapeutic indication.
No. All products sold by Clean Labs USA are strictly for laboratory and in-vitro research use only. They are not drugs, supplements, or food products and are not intended for self-administration or therapeutic use. Purchase constitutes agreement to our Research Use Only terms.
Every order ships with a batch-specific COA. Search our full library at trycleanlabs.com/coa-library.
Store lyophilized powder at −20°C in a sealed vial, protected from light. Shelf life exceeds 24 months under these conditions. Once reconstituted with BAC Water, store at 4°C and use within 28 days. Avoid repeated freeze-thaw cycles.
shop by category.
Clean Labs USA
the standard for research integrity.
Every compound we carry is synthesized to research-grade standards, third-party verified for purity, and shipped with a full certificate of analysis.
melanotan