Semax

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peptide Cognitive Research

semax

ACTH ANALOGUE  ·  10mg / vial
★★★★★

Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from ACTH(4–10), resistant to proteolytic degradation. Shown in preclinical models to upregulate BDNF and modulate monoamine neurotransmitter systems. Synthesized to >99% purity and lyophilized for bench stability. Supplied for in-vitro and laboratory research use only.

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Research Use Only — Not for Human Consumption
Semax has been studied extensively for its activity across multiple neurological pathways:
  • Upregulates BDNF (brain-derived neurotrophic factor) expression in cortical neuron models
  • Modulates dopaminergic and serotonergic neurotransmitter systems in animal studies
  • Demonstrates neuroprotective effects in oxidative stress and ischemia models
  • Enhances memory consolidation and learning parameters in behavioral research
  • Exhibits anti-inflammatory activity via reduced pro-inflammatory cytokine expression
Every batch of Semax is independently tested by a US-based third-party laboratory. Our Certificate of Analysis confirms:
  • Identity: confirmed by HPLC and mass spectrometry
  • Purity: >99% by HPLC
  • Endotoxin: <1 EU/mg
  • Appearance: white to off-white lyophilized powder

Search COA Library →
  • Dolotov OV, et al. (2006). Semax, an analogue of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Research.
  • Melia KR, et al. (1994). ACTH/MSH-derived peptides in learning and memory. Neuropeptides.
  • Grivennikov IA, et al. (2008). Neuroprotective effects of Semax in brain ischemia models. J Mol Neurosci.
Frequently Paired Compounds
Selank
Selank
Anxiolytic Peptide
$44.99
NAD+
NAD+
Longevity Coenzyme
$125.99
BAC Water
BAC Water
Reconstitution Solution
$19.99
Made With
semax
neuropeptide · acth analogue
Semax (Met-Glu-His-Phe-Pro-Gly-Pro) synthesized to >99% purity in a US-based cGMP facility. Resistant to proteolytic degradation and lyophilized for maximum bench stability. Every batch independently tested and COA published publicly. Supplied for in-vitro and laboratory research use only.
an acth analogue for neuroprotection + cognitive research.
Purity>99% by HPLC
FormLyophilized powder
Endotoxin<1 EU/mg
Storage−20°C · 28 days reconstituted
TestingThird-party verified · USA synthesized
FYIResearch Use Only · Not for human use
Semax has been studied extensively for its activity across multiple neurological pathways:
  • Upregulates BDNF (brain-derived neurotrophic factor) expression in cortical neuron models
  • Modulates dopaminergic and serotonergic neurotransmitter systems in animal studies
  • Demonstrates neuroprotective effects in oxidative stress and ischemia models
  • Enhances memory consolidation and learning parameters in behavioral research
  • Exhibits anti-inflammatory activity via reduced pro-inflammatory cytokine expression
Every batch of Semax is independently tested by a US-based third-party laboratory. Our Certificate of Analysis confirms:
  • Identity: confirmed by HPLC and mass spectrometry
  • Purity: >99% by HPLC
  • Endotoxin: <1 EU/mg
  • Appearance: white to off-white lyophilized powder

Search COA Library →
  • Dolotov OV, et al. (2006). Semax, an analogue of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Research.
  • Melia KR, et al. (1994). ACTH/MSH-derived peptides in learning and memory. Neuropeptides.
  • Grivennikov IA, et al. (2008). Neuroprotective effects of Semax in brain ischemia models. J Mol Neurosci.
Support
common questions.

Everything you need to know about Semax for your research. Can't find an answer? Contact our team directly.

Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from ACTH(4–10). It is resistant to proteolytic degradation and has been shown in preclinical models to upregulate BDNF, modulate monoamine neurotransmitter systems, and exert neuroprotective effects. All activity described is from laboratory and animal research only.
Reconstitution and dosing parameters vary depending on the study model. Researchers typically reconstitute with sterile bacteriostatic water. We recommend consulting peer-reviewed literature for protocol design. We do not provide dosing guidance for human use.
No. All products sold by Clean Labs USA are strictly for laboratory and in-vitro research use only. They are not drugs, supplements, or food products and are not intended for self-administration or therapeutic use. Purchase constitutes agreement to our Research Use Only terms.
Every order ships with a batch-specific COA. You can also search our full COA library by SKU or batch number at trycleanlabs.com/coa-library. COAs include HPLC purity data, mass spec confirmation, and endotoxin results.
Store lyophilized Semax powder at −20°C in a sealed vial, away from light and moisture. Under these conditions, shelf life exceeds 24 months. Once reconstituted, store at 4°C and use within 28 days. Do not freeze reconstituted solution.
Clean Labs USA
the standard for research integrity.

Every compound we carry is synthesized to research-grade standards, third-party verified for purity, and shipped with a full certificate of analysis.

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