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kpv
KPV (Lys-Pro-Val) is a C-terminal tripeptide fragment of alpha-melanocyte stimulating hormone (α-MSH). Demonstrates potent anti-inflammatory activity in preclinical models via NF-κB inhibition. Synthesized to >99% purity. For in-vitro research use only.
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Research Use Only — Not for Human Consumption
KPV has been studied across multiple anti-inflammatory and mucosal healing pathways:
- Inhibits NF-κB signaling cascade, reducing pro-inflammatory cytokine expression in preclinical models
- Demonstrates protective activity in inflammatory bowel disease (IBD) models, including colitis
- Modulates macrophage activation and cytokine release in immune cell studies
- Transported intracellularly via the PepT1 peptide transporter, allowing direct mucosal access in gut models
- Shows anti-inflammatory activity independent of melanocortin receptor binding
Every batch of KPV is independently tested by a US-based third-party laboratory. Our Certificate of Analysis (COA) confirms:
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- Identity: confirmed by HPLC and mass spectrometry
- Purity: >99% by HPLC
- Endotoxin: <1 EU/mg
- Appearance: white to off-white lyophilized powder
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- Dalmasso G, et al. (2008). The peptide Lys-Pro-Val blocks NF-κB signaling in intestinal epithelial cells. J Biol Chem.
- Brzoska T, et al. (2008). Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects. Endocr Rev.
- Kannengiesser K, et al. (2008). Melanocortin-derived tripeptide KPV has direct effects on intestinal epithelial cells and immune cells. Regul Pept.
Frequently Paired Compounds
BPC-157
Body Protection Compound
TB-500
Thymosin Beta-4 Analogue
BAC Water
Reconstitution Solution
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kpv
tripeptide · anti-inflammatory
KPV (Lys-Pro-Val) is a C-terminal tripeptide fragment of alpha-melanocyte stimulating hormone (α-MSH), synthesized to >99% purity in a US-based cGMP facility. Every batch independently tested and COA published publicly. Supplied for in-vitro and laboratory research use only.
an anti-inflammatory tripeptide for gut + immune research.
Purity>99% by HPLC
FormLyophilized powder
Endotoxin<1 EU/mg
Storage−20°C · 28 days reconstituted
TestingThird-party verified · USA synthesized
FYIResearch Use Only · Not for human use
KPV has been studied across multiple anti-inflammatory and mucosal healing pathways:
- Inhibits NF-κB signaling cascade, reducing pro-inflammatory cytokine expression in preclinical models
- Demonstrates protective activity in inflammatory bowel disease (IBD) models, including colitis
- Modulates macrophage activation and cytokine release in immune cell studies
- Transported intracellularly via the PepT1 peptide transporter, allowing direct mucosal access in gut models
- Shows anti-inflammatory activity independent of melanocortin receptor binding
Every batch of KPV is independently tested by a US-based third-party laboratory. Our Certificate of Analysis (COA) confirms:
Search COA Library →
- Identity: confirmed by HPLC and mass spectrometry
- Purity: >99% by HPLC
- Endotoxin: <1 EU/mg
- Appearance: white to off-white lyophilized powder
Search COA Library →
- Dalmasso G, et al. (2008). The peptide Lys-Pro-Val blocks NF-κB signaling in intestinal epithelial cells. J Biol Chem.
- Brzoska T, et al. (2008). Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects. Endocr Rev.
- Kannengiesser K, et al. (2008). Melanocortin-derived tripeptide KPV has direct effects on intestinal epithelial cells and immune cells. Regul Pept.
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common questions.
Everything you need to know about KPV for your research. Can't find an answer? Contact our team directly.
KPV (Lys-Pro-Val) is a C-terminal tripeptide fragment of alpha-melanocyte stimulating hormone (α-MSH). In laboratory models it exerts potent anti-inflammatory activity primarily through inhibition of the NF-κB signaling pathway, reducing expression of pro-inflammatory cytokines. It is transported directly into intestinal epithelial cells via the PepT1 transporter. All described activity is from preclinical research only.
Reconstitution and dosing parameters vary by study model and endpoint. Researchers typically reconstitute with sterile bacteriostatic water. We recommend consulting peer-reviewed literature for protocol design. We do not provide dosing guidance for human use.
No. All products sold by Clean Labs USA are strictly for laboratory and in-vitro research use only. They are not drugs, supplements, or food products and are not intended for self-administration or therapeutic use. Purchase constitutes agreement to our Research Use Only terms.
Every order ships with a batch-specific COA. You can also search our full COA library by SKU or batch number at trycleanlabs.com/coa-library. COAs include HPLC purity data, mass spec confirmation, and endotoxin results.
Store lyophilized KPV at −20°C in a sealed vial, away from light and moisture. Shelf life exceeds 24 months under these conditions. Once reconstituted, store at 4°C and use within 28 days. Do not freeze reconstituted solution.
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Every compound we carry is synthesized to research-grade standards, third-party verified for purity, and shipped with a full certificate of analysis.
kpv