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mots-c
MOTS-c is a 16-amino acid peptide encoded within the mitochondrial genome. Activates AMPK signaling to regulate glucose and fatty acid metabolism. Improves insulin sensitivity and enhances physical performance in rodent studies. Synthesized to >98% purity. For research use only.
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Research Use Only — Not for Human Consumption
MOTS-c has been studied in metabolic and mitochondrial research contexts:
- Activates AMPK signaling pathway to regulate glucose and fatty acid oxidation in rodent and cell models
- Improves insulin sensitivity independent of body weight changes in preclinical obesity models
- Enhances physical performance and endurance capacity in aged mouse studies
- Regulates the methionine cycle and folate cycle in mitochondria, influencing one-carbon metabolism
- Circulating levels decline with age; supplementation studies in rodents show restoration of metabolic function
Every batch is independently tested by a US-based third-party laboratory. Our Certificate of Analysis confirms:
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- Identity: confirmed by HPLC and mass spectrometry
- Purity: >98% by HPLC
- Endotoxin: <1 EU/mg
- Appearance: white to off-white lyophilized powder
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- Lee C, et al. (2015). MOTS-c: A Mitochondrial-Derived Peptide Regulating Muscle and Fat Metabolism. Cell Metab.
- Reynolds JC, et al. (2021). Mitochondrial peptide MOTS-c increases adipose fatty acid oxidation and is protective against obesity and insulin resistance. Cell Rep.
- Kim SJ, et al. (2018). Mitochondrially derived peptides as novel regulators of metabolism. J Physiol.
Frequently Paired Compounds
Ipamorelin
GH Secretagogue
IGF-1 LR3
Growth Factor
BAC Water
Reconstitution Solution
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mots-c
peptide · mitochondrial
MOTS-c is a 16-amino acid mitochondrially encoded peptide that acts as a retrograde signal between mitochondria and the nucleus. It activates AMPK and influences cellular metabolism in fat, muscle, and liver tissues. Synthesized to >98% purity for in-vitro and laboratory research use only.
a mitochondrial peptide for metabolic + AMPK signaling research.
Purity>98% by HPLC
FormLyophilized powder
Endotoxin<1 EU/mg
Storage−20°C · 28 days reconstituted
TestingThird-party verified · USA synthesized
FYIResearch Use Only · Not for human use
MOTS-c has been studied in metabolic and mitochondrial research contexts:
- Activates AMPK signaling pathway to regulate glucose and fatty acid oxidation in rodent and cell models
- Improves insulin sensitivity independent of body weight changes in preclinical obesity models
- Enhances physical performance and endurance capacity in aged mouse studies
- Regulates the methionine cycle and folate cycle in mitochondria, influencing one-carbon metabolism
- Circulating levels decline with age; supplementation studies in rodents show restoration of metabolic function
Every batch is independently tested by a US-based third-party laboratory. Our Certificate of Analysis confirms:
Search COA Library →
- Identity: confirmed by HPLC and mass spectrometry
- Purity: >98% by HPLC
- Endotoxin: <1 EU/mg
- Appearance: white to off-white lyophilized powder
Search COA Library →
- Lee C, et al. (2015). MOTS-c: A Mitochondrial-Derived Peptide Regulating Muscle and Fat Metabolism. Cell Metab.
- Reynolds JC, et al. (2021). Mitochondrial peptide MOTS-c increases adipose fatty acid oxidation and is protective against obesity and insulin resistance. Cell Rep.
- Kim SJ, et al. (2018). Mitochondrially derived peptides as novel regulators of metabolism. J Physiol.
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common questions.
Everything you need to know about MOTS-c for your research. Can't find an answer? Contact our team directly.
MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA type-c) is a 16-amino acid peptide encoded by the mitochondrial genome — one of the few known peptides produced from mitochondrial DNA rather than nuclear DNA. It functions as a retrograde signal between mitochondria and the nucleus, influencing systemic metabolic regulation in preclinical research models.
In preclinical studies, MOTS-c activates AMP-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis. AMPK activation by MOTS-c has been shown to increase fatty acid oxidation, improve glucose uptake in muscle, and reduce hepatic glucose output in rodent models. These effects are being studied for their implications in metabolic disease research.
No. All products sold by Clean Labs USA are strictly for laboratory and in-vitro research use only. They are not drugs, supplements, or food products and are not intended for self-administration or therapeutic use. Purchase constitutes agreement to our Research Use Only terms.
Every order ships with a batch-specific COA. Search our full library at trycleanlabs.com/coa-library. COAs include HPLC purity data, mass spec identity confirmation, and endotoxin results.
Store lyophilized powder at −20°C in a sealed vial, away from light and moisture. Shelf life exceeds 24 months under these conditions. Once reconstituted, store at 4°C and use within 28 days. Avoid repeated freeze-thaw cycles of reconstituted solution.
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Every compound we carry is synthesized to research-grade standards, third-party verified for purity, and shipped with a full certificate of analysis.
mots-c
20mg
40mg